الحمل :يمنع استعماله اثناء الحمل
الرضاعة:لا يفضل الاستعمال اثناء الرضاعة
Category D
aceclofenaco
aceclofenaco
It can cause fetal damage administered to pregnant women. The patient should be apprised of the potential harm to the fetus.
In the first and second trimester of pregnancy inhibition of prostaglandin synthesis may negatively affect pregnancy and / or embryo / fetus. Data from epidemiological studies suggest an increased risk of abortion and cardiac malformation and gastroschisis after use of an inhibitor of prostaglandin synthesis in the early stages of gestation. The absolute risk of cardiac malformations was increased from less than 1% to about 1.5%. It seems that the risk increases with dose and duration of treatment.During the first and second trimesters of pregnancy, aceclofenac should not be given unless judged strictly necessary. If you use a woman trying to become pregnant, or during the first and second trimesters of pregnancy, the dose and duration of treatment should be reduced as much as possible. During the third trimester of pregnancy, all inhibitors of prostaglandin synthesis may expose the fetus to: - cardiopulmonary toxicity (with premature closure of the ductus arteriosus and pulmonary hypertension). - Renal dysfunction, which may progress to renal failure with oligohidroamniosis. - Possible prolongation of bleeding time due to an effect of antiplatelet type that can occur even at very low doses. - Inhibition of uterine contractions, which may result in delayed or prolonged labor. Contraindicated during the third trimester of pregnancy. You can alter female fertility and is not recommended in women who are trying to conceive.
Lactation
Avoid
Aceclofenac should not be administered during lactation. There is no
information on secretion in breast milk; however no significant transfer of
aceclofenaco marking (14 C) was observed in rat milk during lactation.
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